The Sculpt Ergonomic Mouse from Microsoft is intended to encourage more natural hand and wrist postures with an angled body designed to remove the wrist from contact with the mousing surface. The sculpted thumb scoop helps the hand maintain this angled position which is intended to reduce pressure on the carpal tunnel. Windows 8 users can benefit from the clearly marked Windows Logo key which provides quick access to the Start Screen. The scroll wheel provides full 4-way scroll control and a convenient Back button is available for quicker navigation. While somewhat similar in design to the discontinued Natural Wireless Laser Mouse 6000, it should be noted that this mouse is smaller in all dimensions than the 6000. While making it easier to transport, by definition it provides less support for most individuals who do not have relatively small hands.

One limitation of this mouse is that it is designed to work only with recent versions of Windows (7, RT, & 8). and a driver download is necessary to take advantage of all the features.

The VerticalMouse 3 was the third generation of the popular Evoluent VerticalMouse which continues to hold its lead in vertical mouse design. The VerticalMouse 3 introduced user-adjustable resolution, accessible using a button and indicator light on the underside of the mouse. This made adjusting pointer speed easier and further improved tracking. The adjustment and indicator have been moved to the side and top of the mouse in sucessive models to facilate easier adjustment.

Although the VerticalMouse 3 is now discontinued it has been replaced by the VerticalMouse 4 and VerticalMouse D, both of which offer the same vertical orientation but now with improved ergonomic contours, multiple sizes, and expanded features.

The Ergonomic Mouse from Microsoft is a basic medium-sized mouse designed for right-handed use. The contoured body provides a resting flange for the thumb to discourage the pinching action that many use when moving their mouse. The mouse is equipped with a clickable textured metal scroll wheel that features crisp detents. Two primary buttons offer the standard Right and Left clicks, with two additional thumb buttons for Back and Forward. Microsoft Mouse and Keyboard Center software facilitates custom programming of all buttons, scroll wheel functions, and DPI settings from 400 to 3200.

The size of the Ergonomic Mouse makes it suitable only for those with small to medium-sized hands.

For those who prefer a wireless connection, especially with a laptop or notebook, the Microsoft Ergonomic mouse is also available in a Bluetooth version.

With Logitech's Performance Mouse MX you can track virtually anywhere - even on a glass desk - with Logitech Darkfield Laser Tracking. Turn the world into your mouse pad. This new mouse also incorporates the Logitech Unifying receiver - the tiny, wireless receiver that stays in your notebook and lets you add devices as you need them. Plug it. Forget it. Add to it.

The micro-USB recharging system lets you use the mouse even when it's charging. You'll fly through documents and Web pages with a single spin. Click-to-click scrolling gives you the precision you need when navigating lists, slides, and images. Designed to fit your hand and put it in a comfortable, natural position, the Performance Mouse MX also has customizable thumb buttons to help you do more, faster. Move backward or forward through Web pages, zoom in or out on photos, and jump between open windows.

Note: Although this is the recommended replacement for the MX Revolution Mouse, the revised shape makes one's hand more pronated (i.e. flatter) on this version than the old MX Revolution Mouse.

Note: The SwitchMouse has been discontinued. The HandshoeMouse SHIFT is an alternative that provides orthopaedic ergonomic support while serving equally well for both right- and left-handed use.

The Switch Mouse integrates two major innovations - a V-shaped base, which puts the wrist and forearm into a slightly more natural pronation for left or right-handed users, and the Extender feature which allow the mouse to 'stretch' to provide some adjustment to the length (but not the width) of the mouse. Other features include a built-in palm support to prevent contact stress on the wrist, four-way scrolling dish, and programmable buttons (requires installation of PC drivers) for user-specified functions. This mouse has a 1600 DPI laser sensor and comes only in a corded model (cord is 2 m in length).